qwave Dense breast tissue can mask more than half of invasive breast cancers on the mammogram – even the digital mammogram.i

 

Do you see the 1.2cm cancer in this patient?
(click on image to enlarge)

Her radiologist did – with SonoCiné.

 

qwave Some have suggested that poor performance, and associated costs and adverse psychological effects of poor performance (of mammography), in women under 50 (primarily dense-breasted women) is reason to forego any type of screening.ii

 

qwave Others have demonstrated that supplemental examinations can find most of the cancers missed by mammography in the dense-breasted patient.iii, iv, v

 

What solution can you offer your patient?

 

Dr. Tom Stavros, Radiologist, Sutter Santa Rosa, CA

 

SonoCiné is a clinically-tested,iv, v automated supplemental ultrasound method that

 

qwave Found 100% more cancers than mammography in a blinded, prospective, multicenter trial of more than 6,400 exams

qwave Found cancers which were 50% smaller than those discovered by mammography (in that same trial)

qwave Did not result in more biopsies than the mammographic screening process

100% increase in cancer detection by including US

  • 6,425 exams
    • Prospective study design
    • Multi-center trial
    • Mammograms read blindly from SonoCiné
  • 100% increase in cancer detection with SonoCiné
    • 23 cancers discovered with mammography alone
    • 46 cancers discovered with mammography + SonoCiné
      • SonoCiné discovered 38 cancers total.
      • SonoCiné discovered 23 mammographically occult cancers.
    • % increase higher than with hand-held study (ACRIN 6666)
    • Fewer distractions
      • Tech acquires images and is not distracted attempting to interpret
      • Physician interprets images and is not distracted attempting to acquire images or interact with patient
  • 22/23 mammographically-occult cancers were invasive
    • SonoCiné was more sensitive for invasive cancers
      • 35/39 invasive cancers were discovered by SonoCiné
      • 17/39 invasive cancers were discovered by mammography
    • Mammography was more sensitive for DCIS
      • 6/7 DCIS were discovered by mammography
      • 3/7 DCIS were discovered by SonoCiné
  • SonoCiné discovered, mammographically-occult invasive cancers were smaller
    • Mean = 10mm
    • Median = 9mm
      • Median-mammographically-discovered invasive cancer = 14mm
      • SonoCiné-discovered, mammographically-occult cancers 73% smaller than mammographically-discovered cancers
  • SonoCiné Positive biopsy rate = 38%
    • PPV for mammography in study = 39%
    • No biopsies performed based on SonoCiné alone
    • SonoCiné prompted complete diagnostic workup (same as mammography)
      • SonoCiné callback rate = 8%
  • Radiologist time = 5min to 10min
    • 5min – 6min for cases with no features (92% of cases)
    • 8min – 12min for cases with features needing further analysis (8% of cases)
  • Results supported by independent panel of readers

SonoCiné is a clinically-tested,iv, v automated supplemental ultrasound method that

 

qwave Adds to your clinical offering without adding to your burden

  • No dedicated room – grow in to your demand
  • Works with existing ultrasound system – use the system that you prefer

qwave Optimize staff contribution

  • Exisiting staff can perform procedure
  • 10min – 15min scan time (tech)
  • 5min – 10min to review (physician)

qwave Maintain reputation as a full-service breast center

qwave No capital investment required
 

iPisano ED, et al, Diagnostic Performance of Digital versus Film Mammography for Breast-Cancer Screening, NEJM, 353;17, October 27, 2005

ii U.S. Preventive Services Task Force , “Screening for Breast Cancer: U.S. Preventive Services Task Force Recommendation Statement”, Annals of Internal Medicine, Vol 151, No. 10, 17 Nov 2009

iii Pisano Wendie A. Berg; Jeffrey D. Blume; Jean B. Cormack; et al., Mammography vs Mammography Alone in Women at Combined Screening With Ultrasound and Elevated Risk of Breast Cancer, JAMA. 2008;299(18):2151-2163

iv Kevin M. Kelly,MD, Judy Dean, MD, W. Scott Comulada, Sung-Jae Lee, “Breast cancer detection using automated whole breast ultrasound and mammography in radiographically dense breasts”, Eur Radiol (2010) 20: 734–742

v Kevin M. Kelly,MD, Judy Dean, MD, W. Scott Comulada, Sung-Jae Lee, “Breast cancer detection: radiologists’ performance using mammography with and without automated whole-breast ultrasound”, Eur Radiol (2010) 20: 2557–2564